Authors: Ramona Jurcău1, Marie Lambinet2, Ioana Jurcău3, Lucian-Daniel Rusu4
1 Department of Pathophysiology, Medicine Faculty, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
2 Graduate student, Medicine Faculty, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj- Napoca, Romania
3 Emergency Clinical Hospital for Children, Cluj-Napoca, Romania
4 Medical Department II, Medicine Faculty, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
Objectives. The objective was to highlight the interest in RR as an adaptogen, from the perspective of the age of participants, in a PubMed evaluation.
Methods. Keywords were selected: “Rhodiola rosea adaptogen” (RRAD); “Rhodiola rosea and stress” (RRS); “Rhodiola rosea and cortisol” (RRC); “Rhodiola rosea and anxiety” (RRA). The PubMed filter chosen was gender (Sex), with sub-filters: human male (HM), human female (HF) and human male and female (HM+HF). Chosen time periods: 1963-1969, 1970-1979, 1980-1989, 1990-1999, 2000-2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018. Analysis criteria: total number of publications (N); average number of publications per year (N/Y).
Results. a) RRAD: differences were significant between: N-HM (p=0.00002); N-HF (p=<0.00001) and N-HM+HF (p=0.00004. b) RRS. Differences were significant between: N-HM (p=0.0004); N-HF (p=0.0002) and N-HM+HF (p=0.0007). c) RRC. Differences were significant between: N-HM (p=0.0406) and N-HF (p=0.0191). d) RRA. Differences were significant between: N-HM (p=0.0012); N-HF (p=0.0007) and N-HM+HF (p=0.0012).
Conclusions. 1) The studies regarding Rhodiola rosea as an adaptogen were analyzed from the first publications posted by PubMed, regarding RRAD, RRS, RRC and RRA, until the end of 2018, for a total period of 32 years. 2) The studies regarding RRAD, RRS, RRC and RRA, although reduced numerically (154), show an increase in time, the highest interest being in RRS, and the lowest one, in RRC. 3) Most studies on RRAD, RRS, RRC and RRA were performed on human subjects, of both genders. 4) This study shows that, although there is still modest interest in publications on RR as an adaptogen, it is still increasing.
Key words: Rhodiola rosea, adaptogen, stress, cortisol, anxiety, PubMed filters, PubMed sub-filters.09-jurcau-II-rhodiola174-178