Authors: Ramona Jurcău1, Ioana Jurcău2
1 Department of Pathophysiology, Medicine Faculty, „Iuliu Hațieganu” University of Medicine and
Pharmacy, Cluj-Napoca, Romania
2 Emergency Clinical Hospital for Children, Cluj-Napoca, Romania
Background. Post-traumatic stress disorder (PTSD) is a severe anxiety syndrome and oxidative stress may be involved.
Aims. The objective was to highlight the relationship between PTSD and oxidative stress, in an approach from the PubMed perspective publication.
Methods. Keywords were selected: PTSD, PTSD and Oxidative stress (PTSD+OS), PTSD and malondialdehyde (PTSD+MDA), PTSD and reactive oxygen species (PTSD+ROS). The PubMed filter chosen was: a) gender (Sex), with subfilters: male (HM), female (HF), male and female (HM+HF); b) Age with sub-filters: 0-18, 19-44, 45-64, >65 and >80 years. Analysis criteria: total number of publication (N); the average number of publications per year (N/Y).
Results. Of the keywords referring to OS, the highest N and N / Y was for PTSD+OS. For PTSD+MDA and PTSD+ROS, N was fluctuating throughout the publication period. For Sex filter, of the key word combinations referring to OS, most publications were for PTDS+OS at M+F. For Age filter, of the key word combinations referring to OS, most publications were for PTSD+OS at 19-44.
Conclusions. 1) Studies on PTSD and Oxidative Stress are very much fewer compared to those for PTSD, but their presence proves interesting in the research in this direction. 2) Among the keyword combinations referring to oxidative stress, those about PTSD + ROS were more numerous than those for PTSD + MDA, both in terms of publication period and total number of publications, which proves a greater concern for research. regarding ROS. 3) All keyword combinations were preferred in the research, being subjects of both genders and age between 19-44 years, which shows an interest for mature adult subjects. 4) Although studies on the relationship between PTSD and oxidative stress are still numerically low, their number is important, proving a growing interest over time in this field of research.
Key words: PTSD, Oxidative stress, malondialdehyde, reactive oxygen species, PubMed.