Authors: Nadina Liana Pop, Daniela-Rodica Mitrea
Affiliation
Department of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Romania
Abstract
Background. Ankylosis Spondylitis (AS) and Juvenile Idiopathic Arthritis (JIA) are both debilitating osteoarticular diseases with a variable degree of genetic transmission that does not produce active diseases in all persons genetically altered. It is considered that for developing an active form of ankylosis spondylitis or juvenile idiopathic arthritis, many factors are implicated such as environmental or living conditions or viral infections. In both diseases, the positive diagnosis is confirmed by considering specific criteria regarding patient’s symptoms, physical examination, laboratory and imagistic tests.
Case presentation. We present a case of two siblings, a 15 year old female and a 17 year old male, without significant personal pathological history, with a confirmed ankylosis spondylitis mother, both having an early onset of the symptoms specific to JIA and AS, respectively. Both patients were evaluated by a rehabilitation medicine specialist; also blood tests and radiological investigation were performed.
Conclusions. The presented case of two siblings with different suspected osteoarticular diseases having a mother with ankylosis spondylitis, suggests that a genetic factor may have high importance in these diseases’ onset.
Keywords: ankylosis spondylitis, juvenile idiopathic arthritis, genetic factor, young patient.
