Authors: Oana Manea, Cristina Bidian, Remus Moldovan, Floris Petru Iliuță, Anca Maria Buduru, Tudor-Valentin Mîrza, Mirela Manea
Affiliation
1 “Carol Davila” University of Medicine and Pharmacy Bucharest, Clinical Hospital CF No 2, Bucharest, Romania
2 Department of Physiology, “Iuliu Haţieganu” University of Medicine and Pharmacy Cluj-Napoca, Romania
3 “Carol Davila” University of Medicine and Pharmacy Bucharest, “Alexandru Obregia” Clinical Hospital of Psychiatry, Bucharest, Romania
4 “Alexandru Obregia” Clinical Hospital of Psychiatry, Bucharest, Romania
5 National Institute of Public Health – Regional Center of Public Health Cluj-Napoca, Romania
Abstract
Background. Depression is a mental disorder characterized by pervasive low mood and loss of pleasure or interest in usual activities, which induces cognitive, especially memory and learning dysfunctions.
Aims. We aimed to study neurobehavioral changes in depressed animals, based on the effects of paliperidone and exercise on the motor memory and learning ability.
Methods. The research was conducted in 4 groups of animals, divided as follows: group I – control animals, group II – animals with reserpine-induced depression, group III – animals with reserpine-induced depression and paliperidone administration, group IV – animals with reserpine-induced depression, paliperidone administration and exercise.
Results. Long-term paliperidone treatment alone and associated with exercise has favorable effects on the learning ability of depressed animals at T30 compared to controls and compared to values at T14. Paliperidone treatment associated or not with exercise has an unfavorable influence on the memory ability of depressed animals at T14 and T30.
Conclusions. Exercise has favorable effects on the learning ability of depressed animals treated with an atypical
antipsychotic.
Keywords: depression, reserpine, paliperidone, Morris test, exercise.
04-manea150-153
