Authors: Oana Manea1, Cristina Bidian2, Remus Moldovan2, Floris Petru Iliuță3, Anca Maria Buduru4, Tudor-Valentin Mîrza5, Mirela Manea3
Affiliation
1 “Carol Davila” University of Medicine and Pharmacy Bucharest, Clinical Hospital CF No 2, Bucharest
2 “Iuliu Haţieganu” University of Medicine and Pharmacy Cluj-Napoca, Department of Physiology
3 “Carol Davila” University of Medicine and Pharmacy Bucharest, “Alexandru Obregia” Clinical Hospital of Psychiatry, Bucharest
4 “Prof. Dr. Al. Obregia” Clinical Hospital of Psychiatry, Bucharest
5 National Institute of Public Health – Regional Center of Public Health Cluj-Napoca
Abstract
Background. Depression is a mental disorder that has an important place among both psychiatric and non-psychiatric disorders.
Aims. We aimed to study, in an experimental model of depression induced in rats, the effects of an atypical antipsychotic associated with exercise on emotional and locomotor behavior.
Methods. The research was conducted in 4 groups of animals, divided as follows: group I – control animals, group II – animals with reserpine-induced depression, group III – animals with reserpine-induced depression and paliperidone administration, group IV – animals with reserpine-induced depression, paliperidone administration and exercise.
Results. Reserpine, used experimentally as a depression-inducing pharmacological agent, determines an increase in emotional behavior and a decrease in locomotor activity. Treatment with paliperidone (an atypical antipsychotic) in sedentary animals with experimental depression induces an increase in emotional behavior and a decrease in locomotor activity. Treatment with paliperidone in exercise-trained animals with experimental depression determines a moderate increase in emotional behavior and the maintenance of locomotor activity within normal limits.
Conclusions. Exercise has favorable effects on locomotor activity in depressed animals treated with an atypical antipsychotic.
Key words: depression, reserpine, paliperidone, open field test, exercise
05-manea110-115Effect of paliperidone treatment and exercise in experimental depression
