Authors: Ramona Jurcău1, Ioana Jurcău2, Nicolae-Alexandru Colceriu3, Ovidiu Mureșan4,
Răzvan-Titus Pîrvan5
Affiliation
1 Department of Pathophysiology, Medicine Faculty, “Iuliu Hațieganu” University of Medicine and
Pharmacy, Cluj-Napoca, Romania
2 Emergency Clinical Hospital for Children, Cluj-Napoca, Romania
3 Faculty of Horticulture, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca
4 Discipline of Oral and Cranio-Maxillofacial Surgery, Medicine Faculty, „Iuliu Hațieganu” University
of Medicine and Pharmacy, Cluj-Napoca, Romania
5 Medicine Faculty,University of Oradea
Abstract
Background. Ginseng (G) is an Asian plant used as an adaptogen, which has the ability to normalize bodily functions compromised by stress. Hypothalamic-pituitary-adrenal axis (HPA) is the main effector of the stress response and cortisol (C) is the most used marker of stress.
Aims. The objective of this study was to evaluate the interest in the relationship between G and HPA, G and cortisol (C) respectively, through an assessment of PubMed studies.
Methods. In order to highlight the relationship between G and stress, the keywords selected for analysis were G+HPA and G+C. The time periods analyzed were from 1970 to 2021. The PubMed filters selected were: Species and Sex.
Results. For G+HPA: publications with Animal filter were the most numerous and had the greatest numerical rise; research dynamic for the sex filter had a lower increase in time. For G+C: publications with Human were the most numerous and had the greatest numerical rise; dynamic researches with HF (Human Female) had the lowest increase in time.
Conclusions. 1) The research on the combination of the keywords G+HPA and G+C falls under the theme of the relationship between G and stress. 2) Research on animals predominated, compared to those on human subjects. 3) Research with subjects from both genders was preferred. 4) The research related to Ginseng and HPA, respectively to Ginseng and Cortisol, although numerically reduced, proves a continuously growing interest of researchers for this subject.
Keywords: Ginseng, Hypothalamic-pituitary-adrenal axis, cortisol, PubMed.
Relationship between Ginseng, hypothalamic pituitary adrenal axis and Cortisol: a PubMed approach
