Ozone therapy and SARS-CoV-2 infection

Authors: Camelia-Manuela Mîrza1, Nicolae Horaţiu Pop2, Adriana Albu3,4, Tudor-Valentin Mîrza5,

Ovidiu Dragoş6, Nikolaos Mavritsakis6



1 Dept. of Functional Sciences, Pathophysiology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

2 Faculty of Physical Education and Sport, Babeş-Bolyai University, Cluj-Napoca, Romania

3 2nd Dept. of Internal Medicine, Cluj-Napoca, Romania

4 Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

5 National Institute of Public Health – Regional Center of Public Health Cluj, Romania

6 1 Decembrie 1918 University, Dept. of Physical Education and Sports, Alba-Iulia, Romania



Ozone is an atmospheric gas occurring in very low quantities. It is formed in parallel with dissociation in the atmosphere. Artificial ozone sources produced in the laboratory are important for its therapeutic effect – virucidal effect, bactericidal effect, fungicidal effect and anti-parasitic effect, as well as for its biocide disinfectant effect.

Ozone therapy can be used in the treatment of the SARS-CoV-2 infection, as non-pharmacologic complementary therapy alongside the pharmacologic therapy in the treatment of COVID-19. The effect mechanism of ozone therapy comprises the rebalancing of the redox homeostasis, induction of formation of IFN-γ and pro-inflammatory cytokines, increase of pulmonary, renal and cardiac vascularization and oxygenation; it acts like an auto-vaccine when administered as minor auto-hemotherapy.


Key words:  ozone, virucidal effect, complementary therapy in COVID-19.



Ozone therapy and SARS-CoV-2 infection