Authors: Cristiana Cojocaru1, Cosmin Popa2, Alina Schenk3, Nicoleta Suciu2, Simona Szasz2
1 Braun Dialysis Centre, Sighișoara, Mureș County, Romania
2 George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Tîrgu-Mureș, Romania
3 Save the Children, Romania
Major depression is an affective disorder with a huge impact both on the quality of life at a personal level and on social or economic functioning. At a neurobiological level, depression may disturb brain activity, which emphasizes even more the need for implementing a highly efficient treatment in the case of major depressive disorder. The purpose of the present article is to present medication and cognitive-behavioral therapy (CBT) effects on the brain and to mention their implications in clinical practice. Research indicates that pharmacological treatment is associated mostly with a rapid remission of some symptoms, and psychotherapy may produce cognitive changes with long-term benefits.
Key words: depression, brain, cognitive-behavioral psychotherapy (CBT), medication, antidepressants.